The London Borough of Tower Hamlets has awarded Canary Wharf Group planning consent for the 4m sq ft (372,660 sq m) North Quay development site.
The site is directly north of 1 Canada Square on the Canary Wharf estate, and adjoins the proposed Isle of Dogs Crossrail station.
The scheme comprises three linked buildings, including two towers of 43 storeys (221 metres) and 37 storeys (209 metres). The scheme will also include a public exhibition space and 57,307 sq ft (5,324 sq m) of shops, restaurants and bars.
Norquil, the freeholder of the site and wholly owned by Canary Wharf Group, was awarded consent yesterday afternoon.
Cesar Pelli, the architect of the original Canary Wharf tower, designed the scheme, in association with SMC Alsop. The development is expected to be completed once the Crossrail station is built